PXD035091

PXD035091 is an original dataset announced via ProteomeXchange.

Title	Comprehensive analysis identifies histone 2A ubiquitination as a marker for aging and pan-cancer prognosis
Description	Ubiquitination is a post-translational modification (PTM) that induces protein degradation or function alteration and plays crucial roles in aging and cancer. Previous ubiquitinomes of aging mainly focused on how does ubiquitination change in drosophila and other lower animals, but how does ubiquitination changes during the aging of higher animals and what causes this changes remain unclear. Here, we profiled a whole-life ubiquitinome data of mouse brain, heart, liver, muscle, and spleen, and an integrative analysis of ubiquitinome data with RNA sequencing data. We found the ubiquitination of protein especially histone 2A (H2A) changes intensely during aging due to the regulated expression of E3 ligases (E3s) and deubiquitylating enzymes (DUBs). We developed two distinct H2A’ E3s/DUBs expression subtypes with different prognosis, DNA damage response (DDR), and tumor microenvironment cell infiltration degrees based on an unsupervised method in pan-cancer. In conclusion, our study provided a temporal resolution ubiquitinome data of mouse aging and revealed the important role of H2A ubiquitination in aging and tumor progression.
HostingRepository	iProX
AnnounceDate	2022-07-05
AnnouncementXML	Submission_2022-07-05_00:53:07.120.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Feiyang Ji
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	ubiquitination signature dipeptidyl lysine
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-05 00:53:00	ID requested
⏵ 1	2022-07-05 00:53:07	announced

Dataset with its publication pending

submitter keyword: Ubiquitination, Histone 2A, Aging, Pan-cancer, DNA damage response

Feiyang Ji
contact affiliation	Zhejiang University
contact email	feiyangji@zju.edu.cn
lab head
Feiyang Ji
contact affiliation	Zhejiang University
contact email	feiyangji@zju.edu.cn
dataset submitter

iProX dataset URI