PXD035089

PXD035089 is an original dataset announced via ProteomeXchange.

Title	Alteration of PFC proteome in MK-801 induced schizophrenia-like adolescent mice
Description	Schizophrenia typically emerges in adolescence or early adulthood. Electrophysiological and several neurochemical changes have linked the GABA deficits to abnormal behaviors induced by NMDAR hypofunction. However, few studies have systematically investigated the molecular basis of GABA deficits, especially during adolescence. To address this issue, we transiently administrated MK-801 to mice on PND 10, which exhibited schizophrenia-relevant deficits in adolescence. Saline treated mice was served as controls. Cortical proteomics was performed on adolescent mice to investigate the proteome alteration.
HostingRepository	iProX
AnnounceDate	2022-07-05
AnnouncementXML	Submission_2022-12-24_20:55:23.861.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ting Xue
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	SYNAPT G2-Si

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-04 20:15:29	ID requested
1	2022-07-04 20:15:44	announced
⏵ 2	2022-12-24 20:55:24	announced	2022-12-25: Update publication information.

Xue T, Wang X, Hu Y, Cheng Y, Li H, Shi Y, Wang L, Yin D, Cui D, Embryonic Deletion of TXNIP in GABAergic Neurons Enhanced Oxidative Stress in PV+ Interneurons in Primary Somatosensory Cortex of Aging Mice: Relevance to Schizophrenia. Brain Sci, 12(10):(2022) [pubmed]

submitter keyword: PFC proteome, Schizophrenia, MK801

Donghong Cui
contact affiliation	Shanghai Mental Health Center
contact email	manyucc@126.com
lab head
Ting Xue
contact affiliation	Shanghai Mental Health Center
contact email	xueting221314@126.com
dataset submitter

iProX dataset URI