PXD035084 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A combination of molecular and clinical parameters provides a new strategy for high-grade serous ovarian cancer patient management |
Description | High-grade serous carcinoma (HGSC) is the most common and deadly subtype of ovarian cancer. Although most patients will initially respond to first-line treatment with a combination of surgery and platinum-based chemotherapy, up to a quarter will be resistant to treatment. We aimed to identify a new strategy to improve HGSC patient management at the time of cancer diagnosis (HGSC-1LTR). Using proteomics in ready-available HGSC tissues, we have identified a molecular signature (TKT, LAMC1 and FUCO) that combined with ready available clinical data is able to predict patient response to first-line treatment (AUC: 0.82). Identification of chemoresistance at the time of diagnosis can facilitate the study of alternative treatments aimed at improving patient outcome. In addition, those patients classified as chemosensitive could undergo standard care with platinum-based agents. Therefore, the HGSC-1LTR strategy can allow optimization of therapeutic decision making and individualize HGSC patients’ care |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:37:18.453.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Eva Borràs |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-07-04 15:07:55 | ID requested | |
1 | 2023-03-10 21:08:25 | announced | |
⏵ 2 | 2023-11-14 08:37:19 | announced | 2023-11-14: Updated project metadata. |
Publication List
Bradbury M, Borr, à, s E, Vilar M, Castellv, í J, S, á, nchez-Iglesias JL, P, é, rez-Benavente A, Gil-Moreno A, Santamaria A, Sabid, ó E, A combination of molecular and clinical parameters provides a new strategy for high-grade serous ovarian cancer patient management. J Transl Med, 20(1):611(2022) [pubmed] |
Keyword List
submitter keyword: proteomics,ovarian cancer |
Contact List
Eduard Sabido |
contact affiliation | UPF-CRG |
contact email | eduard.sabido@crg.eu |
lab head | |
Eva Borràs |
contact affiliation | UPF |
contact email | eva.borras@upf.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD035084 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035084
- Label: PRIDE project
- Name: A combination of molecular and clinical parameters provides a new strategy for high-grade serous ovarian cancer patient management