PXD035084

PXD035084 is an original dataset announced via ProteomeXchange.

Title	A combination of molecular and clinical parameters provides a new strategy for high-grade serous ovarian cancer patient management
Description	High-grade serous carcinoma (HGSC) is the most common and deadly subtype of ovarian cancer. Although most patients will initially respond to first-line treatment with a combination of surgery and platinum-based chemotherapy, up to a quarter will be resistant to treatment. We aimed to identify a new strategy to improve HGSC patient management at the time of cancer diagnosis (HGSC-1LTR). Using proteomics in ready-available HGSC tissues, we have identified a molecular signature (TKT, LAMC1 and FUCO) that combined with ready available clinical data is able to predict patient response to first-line treatment (AUC: 0.82). Identification of chemoresistance at the time of diagnosis can facilitate the study of alternative treatments aimed at improving patient outcome. In addition, those patients classified as chemosensitive could undergo standard care with platinum-based agents. Therefore, the HGSC-1LTR strategy can allow optimization of therapeutic decision making and individualize HGSC patients’ care
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:37:18.453.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eva Borràs
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-04 15:07:55	ID requested
1	2023-03-10 21:08:25	announced
⏵ 2	2023-11-14 08:37:19	announced	2023-11-14: Updated project metadata.

Bradbury M, Borr, à, s E, Vilar M, Castellv, í J, S, á, nchez-Iglesias JL, P, é, rez-Benavente A, Gil-Moreno A, Santamaria A, Sabid, ó E, A combination of molecular and clinical parameters provides a new strategy for high-grade serous ovarian cancer patient management. J Transl Med, 20(1):611(2022) [pubmed]

submitter keyword: proteomics,ovarian cancer

Eduard Sabido
contact affiliation	UPF-CRG
contact email	eduard.sabido@crg.eu
lab head
Eva Borràs
contact affiliation	UPF
contact email	eva.borras@upf.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD035084

PRIDE project URI

• PRIDE
  1. PXD035084
     1. Label: PRIDE project
     2. Name: A combination of molecular and clinical parameters provides a new strategy for high-grade serous ovarian cancer patient management