Updated project metadata. Nowadays, given the globalization as well as the numerous technological developments and innovations that govern the food market, consumer’s expectations, regarding the food they eat, have increased and the information they receive should be at least reliable. This proof-of- concept study is the first analysis of potato tuber tissue using integrated multi-omics approaches across genome-wide DNA methylation, RNA sequencing and quantitative proteomics to obtain the molecular portrait of famous PGI potatoes of Naxos island. Furthermore, we used metagenomics analysis in order to discriminate potato tubers produced in diverse PGI regions based on the distinct microbiological patterns. Hence, we reveal key molecular factors related to harvest and post-harvest through the dynamics of causal models.