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PXD035048

PXD035048 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleContraction of brain pericytes in response to Islet Amyloid PolyPeptide is reversed by pramlintide.
DescriptionThe islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain. In the latter, IAPP is often found in vessels, where it is highly toxic for pericytes, cells that have contractile properties and regulate capillary blood flow. The aim of this study is to assess whether IAPP oligomers alter the morphology and contractility of pericytes using an in vitro brain vasculature model and evaluate the association between IAPP and capillary contraction in human brain tissue.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:17:22.577.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterCharlotte Welinder
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-06-30 07:40:55ID requested
12023-03-10 18:58:43announced
22023-11-14 08:17:23announced2023-11-14: Updated project metadata.
Publication List
Nu, ñ, ez-Diaz C, Pocevi, č, i, ū, t, ė D, Schultz N, Welinder C, Sw, ä, rd K, Wennstr, ö, m M, Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide. Mol Brain, 16(1):25(2023) [pubmed]
Keyword List
submitter keyword: amylin, vasculopathy, blood-brain barrier, diabetes, LC-MS/MS
Contact List
Malin Wennström
contact affiliationClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
contact emailMalin.wennstrom@med.lu.se
lab head
Charlotte Welinder
contact affiliationDept. of Oncology, Clinical Sciences, Lund University, 221 85 Lund, Sweden
contact emailcharlotte.welinder@med.lu.se
dataset submitter
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Dataset FTP location
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