PXD035048 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Contraction of brain pericytes in response to Islet Amyloid PolyPeptide is reversed by pramlintide. |
Description | The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain. In the latter, IAPP is often found in vessels, where it is highly toxic for pericytes, cells that have contractile properties and regulate capillary blood flow. The aim of this study is to assess whether IAPP oligomers alter the morphology and contractility of pericytes using an in vitro brain vasculature model and evaluate the association between IAPP and capillary contraction in human brain tissue. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:17:22.577.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Charlotte Welinder |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-06-30 07:40:55 | ID requested | |
1 | 2023-03-10 18:58:43 | announced | |
⏵ 2 | 2023-11-14 08:17:23 | announced | 2023-11-14: Updated project metadata. |
Publication List
Nu, ñ, ez-Diaz C, Pocevi, č, i, ū, t, ė D, Schultz N, Welinder C, Sw, ä, rd K, Wennstr, ö, m M, Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide. Mol Brain, 16(1):25(2023) [pubmed] |
Keyword List
submitter keyword: amylin, vasculopathy, blood-brain barrier, diabetes, LC-MS/MS |
Contact List
Malin Wennström |
contact affiliation | Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden |
contact email | Malin.wennstrom@med.lu.se |
lab head | |
Charlotte Welinder |
contact affiliation | Dept. of Oncology, Clinical Sciences, Lund University, 221 85 Lund, Sweden |
contact email | charlotte.welinder@med.lu.se |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD035048 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035048
- Label: PRIDE project
- Name: Contraction of brain pericytes in response to Islet Amyloid PolyPeptide is reversed by pramlintide.