PXD035026 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics Characterization of Longitudinal CSF from ALS Fast and Slow Progressors |
Description | Each CSF sample was concentrated and added to a multiple affinity removal spin cartridge .The eluates were subjected to a buffer exchange and proteins were reduced using DTT and alkylated using iodoacetamide. Digestions were performed using trypsin. CSF from patients with amyotrophic lateral sclerosis (ALS) was characterized via LC-MS/MS. Biomarkers were identified to differentiate fast and slow progressors. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:26:15.781.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Krystine Mansfield |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-06-30 07:01:15 | ID requested | |
1 | 2024-01-26 07:39:31 | announced | |
⏵ 2 | 2024-10-22 06:26:16 | announced | 2024-10-22: Updated project metadata. |
Publication List
Vu L, Garcia-Mansfield K, Pompeiano A, An J, David-Dirgo V, Sharma R, Venugopal V, Halait H, Marcucci G, Kuo YH, Uechi L, Rockne RC, Pirrotte P, Bowser R, Proteomics and mathematical modeling of longitudinal CSF differentiates fast versus slow ALS progression. Ann Clin Transl Neurol, 10(11):2025-2042(2023) [pubmed] |
10.1002/acn3.51890; |
Keyword List
submitter keyword: Amyotrophic Lateral Sclerosis, mass spectrometry, CSF |
Contact List
Patrick Pirrotte |
contact affiliation | Translational Genomics Research Institute (TGen) |
contact email | ppirrotte@tgen.org |
lab head | |
Krystine Mansfield |
contact affiliation | TGen |
contact email | kgarcia@tgen.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD035026 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035026
- Label: PRIDE project
- Name: Proteomics Characterization of Longitudinal CSF from ALS Fast and Slow Progressors