PXD034938

PXD034938 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
Description	Dysregulation of the Notch-RBPJ signaling pathway has been found associated with various human diseases including cancers; however, precisely how this key signaling pathway is fine-tuned via its interactors and modifications is still largely unknown. In this study, using a proteomic approach, we identified FBXO42 as a novel RBPJ interactor. FBXO42 promotes RBPJ polyubiquitination on lysine (K) 175 via K63 linkage, which enhances the association of RBPJ with chromatin remodeling complexes and induces a global chromatin relaxation. Genetically depleting FBXO42 or pharmacologically targeting its E3 ligase activity attenuates the Notch signaling-related leukemia development in vivo. Taken together, our findings not only revealed FBXO42 as a critical regulator of the Notch pathway by modulating RBPJ-dependent global chromatin landscape changes, but also provide insights into the therapeutic intervention of the Notch pathway for leukemia treatment.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:54:34.111.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD034938
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	bian weixiang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-27 02:50:20	ID requested
1	2022-10-13 08:11:04	announced
⏵ 2	2023-11-14 07:54:35	announced	2023-11-14: Updated project metadata.

Publication List

Jiang H, Bian W, Sui Y, Li H, Zhao H, Wang W, Li X, FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ. Sci Adv, 8(38):eabq4831(2022) [pubmed]
10.6019/PXD034938;

Jiang H, Bian W, Sui Y, Li H, Zhao H, Wang W, Li X, FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ. Sci Adv, 8(38):eabq4831(2022) [pubmed]

10.6019/PXD034938;

Keyword List

submitter keyword: RBPJ,Notch signaling,ubiquitination

submitter keyword: RBPJ,Notch signaling,ubiquitination

Contact List

Xu Li
contact affiliation	School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China
contact email	lixu@westlake.edu.cn
lab head
bian weixiang
contact affiliation	Westlake University
contact email	bianweixiang@westlake.edu.cn
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD034938
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD034938

PRIDE project URI

Repository Record List

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