PXD034933

PXD034933 is an original dataset announced via ProteomeXchange.

Title	A proteomic platform unveils the brain glycogen phosphorylase as a potential metabolic target for glioblastoma multiforme
Description	In the last few years, several efforts have been ended to identify original strategies against gli-oblastoma multiforme (GBM): this requires a more detailed investigation of the molecular mechanism of GBM so that novel targets can be identified for new possible therapeutic agents. Here, using a combined proteomic approach, we evaluated the ability of a blood brain barrier permeable 2,3-benzodiazepin-4-one, called 1g, to interfere with the activity and the expression of brain glycogen phosphorylase (PYGB) on U87MG cell line in parallel with the capability of this compound to inhibit the cell growth and cycle. Thus, our results highlighted PYGB as a potential metabolic target in GBM prompting 1g as a capable anticancer drug thanks to its ability to nega-tively modulate the uptake and metabolism of glucose, the so called “Warburg effect”, whose increase is considered a common feature of cancer cells in respect of their normal counterparts.
HostingRepository	PRIDE
AnnounceDate	2022-08-11
AnnouncementXML	Submission_2022-08-11_06:38:19.828.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Giusy Ferraro
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-27 02:46:00	ID requested
⏵ 1	2022-08-11 06:38:20	announced

Ferraro G, Mozzicafreddo M, Ettari R, Corsi L, Monti MC, A Proteomic Platform Unveils the Brain Glycogen Phosphorylase as a Potential Therapeutic Target for Glioblastoma Multiforme. Int J Mol Sci, 23(15):(2022) [pubmed]

submitter keyword: Glioblastoma multiforme, target identification, proteomics, 2,3-benzodiazepin-4-one, glycogen phosphorylase

Maria Chiara Monti
contact affiliation	Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy
contact email	mcmonti@unisa.it
lab head
Giusy Ferraro
contact affiliation	Università degli Studi di Salerno
contact email	gferraro@unisa.it
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD034933
     1. Label: PRIDE project
     2. Name: A proteomic platform unveils the brain glycogen phosphorylase as a potential metabolic target for glioblastoma multiforme