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PXD034908

PXD034908 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe muscle proteome reflects changes in mitochondrial function, cellular stress and proteolysis after 14 days of unilateral lower limb immobilization in active young men
DescriptionSkeletal muscle unloading due to joint immobilization induces skeletal muscle atrophy. However, the skeletal muscle proteome response to limb immobilization has not been investigated using SWATH methods. This study quantitatively characterized the muscle proteome at baseline, and after 3 and 14 d of unilateral lower limb (knee-brace) immobilization in 18 healthy young men (25.4 ±5.5 y, 81.2 ±11.6 kg). All muscle biopsies were obtained from the vastus lateralis muscle. Unilateral lower limb immobilization was preceded by four-weeks of exercise training to standardise acute training history, and 7 days of dietary provision to standardise energy/macronutrient intake. Dietary intake was also standardised/provided throughout the 14 d immobilization period.
HostingRepositoryPRIDE
AnnounceDate2022-08-26
AnnouncementXMLSubmission_2022-08-25_18:01:23.305.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTHIRI ZAW
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentTripleTOF 6600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-06-26 07:39:14ID requested
12022-08-25 18:01:23announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: SWATH, human, skeletal muscle, immobilisation, muscle atrophy
Contact List
Vernon Coffey
contact affiliationExercise and Sports Science Faculty of Health Sciences and Medicine Bond University, Gold Coast, Queensland, 4229 Australia
contact emailvcoffey@bond.edu.au
lab head
THIRI ZAW
contact affiliationAUSTRALIAN PROTEOME ANALYSIS FACILITY, MQ UNIVERSITY
contact emailthiri.zaw@mq.edu.au
dataset submitter
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Dataset FTP location
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