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PXD034900

PXD034900 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleImpact of immunoproteasome impairment on microglia cell function
DescriptionThe ubiquitin-proteasome system maintains the functional proteome of the cells by the clearance of damaged, misfolded, old and/or unneeded proteins. This is particularly important in the brain where protein accumulation has a hallmark of many neurodegenerative diseases that drives neuroinflammation. Microglia are the resident immune cells of the central nervous system and play a major role in the regulation of brain homeostasis via constitutive expression of standard proteasomes and immunoproteasomes (IP). Nevertheless, the impact of IP function on the innate immunity of CNS is not well described. Here, we analyzed ubiquitylated proteins in IP deficient microglia upon enrichment and under different conditions to identify the proteins preferentially degraded by the IP and to investigate the impact of the accumulation of these proteins on microglia function.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:02:33.632.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSimone Venz
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListubiquitination signature tetrapeptidyl lysine; N-ethylmaleimide derivatized cysteine; ubiquitination signature dipeptidyl lysine; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-06-26 07:31:04ID requested
12023-03-10 13:02:11announced
22023-11-14 08:02:35announced2023-11-14: Updated project metadata.
Publication List
Ç, etin G, Studencka-Turski M, Venz S, Schormann E, Junker H, Hammer E, V, ö, lker U, Ebstein F, Kr, ü, ger E, Immunoproteasomes control activation of innate immune signaling and microglial function. Front Immunol, 13():982786(2022) [pubmed]
Keyword List
submitter keyword: neuroinflammation, proteomics, immunoproteasome, CNS, UPS,microglia, proteostasis
Contact List
Simone Venz
contact affiliationInstitute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, 17475, Greifswald, Germany
contact emailsimone.venz@med.uni-greifswald.de
lab head
Simone Venz
contact affiliationInstitute of Medical Biochemistry and Molecular Biology - University Medicine Greifswald
contact emailsimone.venz@med.uni-greifswald.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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