PXD034900 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Impact of immunoproteasome impairment on microglia cell function |
Description | The ubiquitin-proteasome system maintains the functional proteome of the cells by the clearance of damaged, misfolded, old and/or unneeded proteins. This is particularly important in the brain where protein accumulation has a hallmark of many neurodegenerative diseases that drives neuroinflammation. Microglia are the resident immune cells of the central nervous system and play a major role in the regulation of brain homeostasis via constitutive expression of standard proteasomes and immunoproteasomes (IP). Nevertheless, the impact of IP function on the innate immunity of CNS is not well described. Here, we analyzed ubiquitylated proteins in IP deficient microglia upon enrichment and under different conditions to identify the proteins preferentially degraded by the IP and to investigate the impact of the accumulation of these proteins on microglia function. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:02:33.632.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Simone Venz |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | ubiquitination signature tetrapeptidyl lysine; N-ethylmaleimide derivatized cysteine; ubiquitination signature dipeptidyl lysine; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-06-26 07:31:04 | ID requested | |
1 | 2023-03-10 13:02:11 | announced | |
⏵ 2 | 2023-11-14 08:02:35 | announced | 2023-11-14: Updated project metadata. |
Publication List
Ç, etin G, Studencka-Turski M, Venz S, Schormann E, Junker H, Hammer E, V, ö, lker U, Ebstein F, Kr, ü, ger E, Immunoproteasomes control activation of innate immune signaling and microglial function. Front Immunol, 13():982786(2022) [pubmed] |
Keyword List
submitter keyword: neuroinflammation, proteomics, immunoproteasome, CNS, UPS,microglia, proteostasis |
Contact List
Simone Venz |
contact affiliation | Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, 17475, Greifswald, Germany |
contact email | simone.venz@med.uni-greifswald.de |
lab head | |
Simone Venz |
contact affiliation | Institute of Medical Biochemistry and Molecular Biology - University Medicine Greifswald |
contact email | simone.venz@med.uni-greifswald.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD034900
- Label: PRIDE project
- Name: Impact of immunoproteasome impairment on microglia cell function