PXD034882

PXD034882 is an original dataset announced via ProteomeXchange.

Title	Tandem Mass Tag-Based Quantitative Proteomic Profiling Identifies Novel Serum Biomarkers of Drug-Induced Liver Injury in Humans
Description	Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. In this study we identify, confirm, and replicate the biomarker performance characteristics of candidate proteins in a cohort of patients with DILI at onset (DO; n = 133) and follow-up (DF; n = 120), acute non-DILI at onset (NDO; n = 63) and follow-up (NDF; n = 42), and healthy volunteers (HV; n = 104). Area under the receiver operating characteristic curve (AUC) for cytoplasmic aconitate hydratase; argininosuccinate synthase; carbamoylphosphate synthase, fumarylacetoacetase; fructose-1,6-bisphosphatase 1 (FBP1) across cohorts achieves near complete separation (range: 0.94 - 0.99) of DO and HV. In addition, we show that FBP1 alone or in combination with glutathione S-transferase A1 and leukocyte cell derived chemotaxin 2 could potentially assist in clinicla diagnosis by distinguishing NDO from DO (AUC range: 0.65 – 0.78), but further technical and clinical validation of these candidate biomarkers is needed.
HostingRepository	PanoramaPublic
AnnounceDate	2024-01-04
AnnouncementXML	Submission_2024-01-04_11:58:18.005.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Joel Federspiel
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Label:13C(6)15N(2); Label:13C(6)15N(4)
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-25 23:13:10	ID requested
1	2023-01-26 11:28:31	announced
⏵ 2	2024-01-04 11:58:18	announced	: Added PubMed Id

Ravindra KC, Vaidya VS, Wang Z, Federspiel JD, Virgen-Slane R, Everley RA, Grove JI, Stephens C, Ocana MF, Robles-D, í, az M, Isabel Lucena M, Andrade RJ, Atallah E, Gerbes AL, Weber S, Cortez-Pinto H, Fowell AJ, Hussaini H, Bjornsson ES, Patel J, Stirnimann G, Verma S, Elsharkawy AM, Griffiths WJH, Hyde C, Dear JW, Aithal GP, Ramaiah SK, Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans. Nat Commun, 14(1):1215(2023) [pubmed]

submitter keyword: DILI, Biomarker, Liver Disease

Mireia Fernandez Ocana
contact affiliation	Pfizer Inc.
contact email	mireia.fernandezocana@pfizer.com
lab head
Joel Federspiel
contact affiliation	Pfizer, Inc.
contact email	joel.federspiel@pfizer.com
dataset submitter

Panorama Public dataset URI