PXD034877

PXD034877 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic Characterization of Human Milk Fat Globule Membrane Proteins during a 12 Month Lactation Period
Description	The milk fat globule membrane (MFGM) contains proteins which have been implicated in a variety of health benefits. Milk fat globule membrane proteins were isolated from human milk during a 12 month lactation period and subjected to in solution digestion and liquid chromatography tandem mass spectrometry analysis. Data were pooled, and our results showed that 191 proteins were identified. Relative quantification of the identified MFGM proteins during the course of lactation was performed by label free spectral counting and differentiation expression analysis, which showed some proteins decreasing during the course of lactation whereas some increased or remained at a relatively constant level. The human MFGM proteins are distributed between intracellular, extracellular, and membrane-associated proteins, and they are mainly involved in cell communication and signal transduction, immune function, metabolism and energy production. This study provides more insights into the dynamic composition of human MFGM proteins, which in turn will enhance our understanding of the physiological significance of MFGM proteins.
HostingRepository	MassIVE
AnnounceDate	2022-06-24
AnnouncementXML	Submission_2022-06-24_11:53:45.766.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Brett Phinney
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Oxidation
Instrument	LTQ

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-24 10:44:13	ID requested
⏵ 1	2022-06-24 11:53:46	announced

Publication List

Liao Y, Alvarado R, Phinney B, L, ö, nnerdal B, Proteomic characterization of human milk fat globule membrane proteins during a 12 month lactation period. J Proteome Res, 10(8):3530-41(2011) [pubmed]

Liao Y, Alvarado R, Phinney B, L, ö, nnerdal B, Proteomic characterization of human milk fat globule membrane proteins during a 12 month lactation period. J Proteome Res, 10(8):3530-41(2011) [pubmed]

Keyword List

submitter keyword: Lactation, Human Milk, MFGM

submitter keyword: Lactation, Human Milk, MFGM

Contact List

Bo Lonnerdal
contact affiliation	Department of Nutrition University of California, Davis, Californi
contact email	bllonnerdal@ucdavis.edu
lab head
Brett Phinney
contact affiliation	UC Davis
contact email	brettsp@ucdavis.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000089722/