PXD034867

PXD034867 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling skin mucus of European eel Anguilla anguilla infected with Anguillid herpesvirus
Description	Anguillid herpesvirus 1 (AngHV) is an important viral pathogen of eel. This study was conducted to investigate the molecular mechanisms and immune response at the protein levels in the skin mucus of AngHV infected Anguilla anguilla. TMT-labelling proteomics with the liquid chromatographytandem mass spectrometry (LC-MS/MS) was used for protein quantitative identification. And the quantitative protein amount was detected by parallel reaction monitoring (PRM) analysis. A total of 3486 proteins were identified, of which 2935 were quantified. When a protein fold change greater than 1.3 or less than 0.76 was considered to indicate a differentially expressed protein (DEP), 187 up-regulated proteins and 126 down-regulated proteins were detected, and most of the DEPs were enriched in CAMs pathway, intestinal immune pathway, herpes simplex virus 1 infection pathway, phagosome pathway and p53 signaling pathway. The results of the DEPs detected by PRM were highly consistent with that of the TMT-labelled quantitative proteomic analysis results.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:15:34.189.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ying-Ying Li
SpeciesList	scientific name: Anguilla anguilla x Anguilla rostrata; NCBI TaxID: 1436734;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-24 08:35:55	ID requested
1	2023-03-10 13:22:23	announced
⏵ 2	2023-11-14 08:15:38	announced	2023-11-14: Updated project metadata.

Li YY, Yang JX, Chen X, Chen Q, Song TY, Ge JQ, Infected with Anguillid Herpesvirus. Int J Mol Sci, 23(19):(2022) [pubmed]

submitter keyword: Anguilla anguilla

Anguillid herpesvirus

TMT-labelled

proteomic

skin mucus

Jun-Qing Ge
contact affiliation	Institute of Biotechnology, Fujian Academy of Agricultural Sciences, China;
contact email	jqge@163.com
lab head
Ying-Ying Li
contact affiliation	Institute of Biotechnology, Fujian Academy of Agricultural Sciences
contact email	liyingying80@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD034867

PRIDE project URI

• PRIDE
  1. PXD034867
     1. Label: PRIDE project
     2. Name: Proteomic profiling skin mucus of European eel Anguilla anguilla infected with Anguillid herpesvirus