PXD034846

PXD034846 is an original dataset announced via ProteomeXchange.

Title	Proteomics analysis of cerebrospinal fluid (CSF) from multiple sclerosis patients
Description	Innovative pro-regenerative treatment strategies for progressive multiple sclerosis (PMS), combining neuroprotection and immunomodulation, represents an unmet need. Neural precursor cells (NPCs) transplanted in animal models of multiple sclerosis promote neuroprotection and remyelination by releasing molecules sustaining trophic support and neural plasticity. We present the results of STEMS, a single dose escalation phase I clinical trial, evaluating the feasibility, safety, and tolerability of intrathecally transplanted human fetal NPCs (hfNPCs) in 12 PMS patients.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:01:09.826.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD034846
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Annapaola Andolfo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-22 14:59:27	ID requested
1	2022-11-18 11:06:48	announced
⏵ 2	2023-11-14 09:01:10	announced	2023-11-14: Updated project metadata.

10.6019/PXD034846;

submitter keyword: Progressive multiple sclerosis, cerebrospinal fluid, neural stem cells, transplantation, quantitative proteomics

Gianvito Martino
contact affiliation	Neuroimmunology Unit Institute of Experimental Neurology San Raffaele Scientific Institute Via Olgettina 60 Milan 20132, Italy
contact email	martino.gianvito@hsr.it
lab head
Annapaola Andolfo
contact affiliation	Ospedale San Raffaele
contact email	andolfo.annapaola@hsr.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD034846

PRIDE project URI

• PRIDE
  1. PXD034846
     1. Label: PRIDE project
     2. Name: Proteomics analysis of cerebrospinal fluid (CSF) from multiple sclerosis patients