PXD034818 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | LC-MSMS of primary breast cancer samples |
Description | CD8 T cells drive the anti-cancer immune response through the recognition of MHC I-associated peptides. In order to identify relevant targets for cancer immunotherapy in breast cancer, we characterized the immunopeptidome of 26 primary breast cancer samples from two different subtypes, hormone-receptor positive (n=14) and triple negative (n=12). We were able to identify tumor-specific and tumor associated antigens in both subtypes of breast cancer, which can be used for the development of anti-cancer vaccines or as targets for engineered T-cells. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:14:29.928.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD034818 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Courcelles Mathieu |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; deamidated residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-06-22 02:02:35 | ID requested | |
1 | 2023-11-15 11:06:04 | announced | |
⏵ 2 | 2024-10-22 06:14:30 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1172/jci166740; |
10.6019/PXD034818; |
Kina E, Laverdure JP, Durette C, Lanoix J, Courcelles M, Zhao Q, Apavaloaei A, Larouche JD, Hardy MP, Vincent K, Gendron P, Hesnard L, Th, é, riault C, Ruiz Cuevas MV, Ehx G, Thibault P, Perreault C, Breast cancer immunopeptidomes contain numerous shared tumor antigens. J Clin Invest, 134(1):(2024) [pubmed] |
Keyword List
submitter keyword: LC-MSMS,Breast cancer, immunopeptidome, MHC class I |
Contact List
Pierre Thibault |
contact affiliation | All liquid chromatography MS/MS (LC-MS/MS) data were searched against the relevant database using PEAKS 10.5 or Peaks X Pro (Bioinformatics Solution Inc.). For peptide identification, tolerance was set at 10 ppm and 0.01 Da for precursor and fragment ions, respectively. The occurrences of oxidation (M), deamidation and TMT modification were set as variable modifications |
contact email | pierre.thibault@umontreal.ca |
lab head | |
Courcelles Mathieu |
contact affiliation | IRIC |
contact email | mathieu.courcelles@umontreal.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD034818
- Label: PRIDE project
- Name: LC-MSMS of primary breast cancer samples