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PXD034818

PXD034818 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLC-MSMS of primary breast cancer samples
DescriptionCD8 T cells drive the anti-cancer immune response through the recognition of MHC I-associated peptides. In order to identify relevant targets for cancer immunotherapy in breast cancer, we characterized the immunopeptidome of 26 primary breast cancer samples from two different subtypes, hormone-receptor positive (n=14) and triple negative (n=12). We were able to identify tumor-specific and tumor associated antigens in both subtypes of breast cancer, which can be used for the development of anti-cancer vaccines or as targets for engineered T-cells.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:14:29.928.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD034818
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterCourcelles Mathieu
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; deamidated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-06-22 02:02:35ID requested
12023-11-15 11:06:04announced
22024-10-22 06:14:30announced2024-10-22: Updated project metadata.
Publication List
10.1172/jci166740;
10.6019/PXD034818;
Kina E, Laverdure JP, Durette C, Lanoix J, Courcelles M, Zhao Q, Apavaloaei A, Larouche JD, Hardy MP, Vincent K, Gendron P, Hesnard L, Th, é, riault C, Ruiz Cuevas MV, Ehx G, Thibault P, Perreault C, Breast cancer immunopeptidomes contain numerous shared tumor antigens. J Clin Invest, 134(1):(2024) [pubmed]
Keyword List
submitter keyword: LC-MSMS,Breast cancer, immunopeptidome, MHC class I
Contact List
Pierre Thibault
contact affiliationAll liquid chromatography MS/MS (LC-MS/MS) data were searched against the relevant database using PEAKS 10.5 or Peaks X Pro (Bioinformatics Solution Inc.). For peptide identification, tolerance was set at 10 ppm and 0.01 Da for precursor and fragment ions, respectively. The occurrences of oxidation (M), deamidation and TMT modification were set as variable modifications
contact emailpierre.thibault@umontreal.ca
lab head
Courcelles Mathieu
contact affiliationIRIC
contact emailmathieu.courcelles@umontreal.ca
dataset submitter
Full Dataset Link List
Dataset FTP location
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Repository Record List
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