PXD034803

PXD034803 is an original dataset announced via ProteomeXchange.

Title	Glucose-dependent insulinotropic polypeptide effects in type 1 diabetes
Description	Glucose-dependent insulinotropic polypeptide (GIP) has been proposed to exert insulin-independent effects on lipid and bone metabolism. We investigated the effect of a 6-day s.c. GIP infusion on circulating lipids, white adipose tissue (WAT), brown adipose tissue (BAT), hepatic fat content, and inflammatory markers in patients with type 1 diabetes. In a randomized, placebo-controlled, double-blind, crossover study, 20 men with type 1 diabetes underwent a 6-day continuous s.c. infusion with GIP (6 pmol/kg/min) and placebo (saline), with an interposed seven-day washout period. Each intervention period involved three study days: Day 0 (baseline measurements, a baseline abdominal adipose tissue biopsy and blood sampling), Day 1 (fasting blood sample after 24 hours infusion), and Day 6 (fasting blood sample, an abdominal adipose tissue biopsy).
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:56:35.622.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vladimir Gorshkov
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-21 14:04:48	ID requested
1	2022-11-08 09:54:37	announced
⏵ 2	2023-11-14 08:56:36	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: Human, multiomics, blood plasma, diabetes

Frank Kjeldsen
contact affiliation	Profeesor Department of Biochemistry and Molecular Biology University of Southern Denmark Odense, Denmark
contact email	frankk@bmb.sdu.dk
lab head
Vladimir Gorshkov
contact affiliation	University of Southern Denmark
contact email	vgor@bmb.sdu.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD034803

PRIDE project URI

• PRIDE
  1. PXD034803
     1. Label: PRIDE project
     2. Name: Glucose-dependent insulinotropic polypeptide effects in type 1 diabetes