PXD034803 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Glucose-dependent insulinotropic polypeptide effects in type 1 diabetes |
Description | Glucose-dependent insulinotropic polypeptide (GIP) has been proposed to exert insulin-independent effects on lipid and bone metabolism. We investigated the effect of a 6-day s.c. GIP infusion on circulating lipids, white adipose tissue (WAT), brown adipose tissue (BAT), hepatic fat content, and inflammatory markers in patients with type 1 diabetes. In a randomized, placebo-controlled, double-blind, crossover study, 20 men with type 1 diabetes underwent a 6-day continuous s.c. infusion with GIP (6 pmol/kg/min) and placebo (saline), with an interposed seven-day washout period. Each intervention period involved three study days: Day 0 (baseline measurements, a baseline abdominal adipose tissue biopsy and blood sampling), Day 1 (fasting blood sample after 24 hours infusion), and Day 6 (fasting blood sample, an abdominal adipose tissue biopsy). |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:56:35.622.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Vladimir Gorshkov |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-06-21 14:04:48 | ID requested | |
1 | 2022-11-08 09:54:37 | announced | |
⏵ 2 | 2023-11-14 08:56:36 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Human, multiomics, blood plasma, diabetes |
Contact List
Frank Kjeldsen |
contact affiliation | Profeesor Department of Biochemistry and Molecular Biology University of Southern Denmark Odense, Denmark |
contact email | frankk@bmb.sdu.dk |
lab head | |
Vladimir Gorshkov |
contact affiliation | University of Southern Denmark |
contact email | vgor@bmb.sdu.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD034803
- Label: PRIDE project
- Name: Glucose-dependent insulinotropic polypeptide effects in type 1 diabetes