PXD034792

PXD034792 is an original dataset announced via ProteomeXchange.

Title	A peptide-based tolerizing vaccine against autoimmune arthritis directly interacting with antigen-specific T cells
Description	A longstanding goal has been to find an antigen-specific preventive therapy, i.e., a vaccine, for autoimmune diseases. Major hindrances have so far been to select natural regulatory antigen targets and side-effects induced by clustering the T cell receptor (TCR) or activating the costimulatory signals. Here we show that the administration of a mouse major histocompatibility complex class II protein binding a unique galactosylated collagen type II (COL2) peptide (Aq-galCOL2) directly interacts with the antigen specific TCR, and expands peripheral regulatory T cells, displaying a potent dominant suppressive effect and protection of collagen induced arthritis. The therapeutic effect is dominant and tissue specific as it is possible to transfer the effect with induced regulatory T cells and downregulate autoimmune arthritis induced by other antigens than COL2 or by passive transfer of antibodies. Thus, the here described tolerogenic approach may be a promising dominant antigen-specific therapy for RA, and in principle, for autoimmune diseases in general.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:01:04.497.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christian Beusch
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-21 08:18:01	ID requested
1	2023-06-15 09:17:57	announced
⏵ 2	2023-11-14 09:01:05	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: autoimmune arthritis, arthritis,antigen-specific T cells, vaccine

Rikard Holmdahl
contact affiliation	Division of Medical Inflammation Research, Dept. Medical Biochemistry and Biophysics, Karolinska Institute, Sweden
contact email	rikard.holmdahl@ki.se
lab head
Christian Beusch
contact affiliation	Division of Chemistry I Department of Medical Biochemistry & Biophysics Karolinska Institutet
contact email	christian.beusch@ki.se
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD034792
     1. Label: PRIDE project
     2. Name: A peptide-based tolerizing vaccine against autoimmune arthritis directly interacting with antigen-specific T cells