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PXD034788

PXD034788 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLarge-Scale Immuno-Peptidome Analysis Reveals Recurrent Post-Translational Splicing of Cancer and Immune-Associated Genes
DescriptionPost translational spliced peptides bound to the HLA are unique type of peptides, shown in cancer, for HLA-class-I. Thus far, no consensus has been reached on the extent to which post-translational spliced peptides (PTSPs) occur, stirring significant debate. Furthermore, the role of the HLA-class-II pathway has been studied only in diabetes. Here, we exploit our large-scale cancer peptidomics database and devise a pipeline to filter spliced peptide predictions, to identify recurring spliced peptides, both for HLA-class-I and -II. Our results indicate that HLA-Class-I spliced peptides account for a low percentage (4.4%) of the immunopeptidome, yet are larger in number relative to other types of identified aberrant peptides. Therefore, spliced peptides contribute significantly to the repertoire of presented peptides in cancer cells. In addition, HLA-class-II bound spliced peptides were identified as well, but to a lower extent (0.6%).
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:47:36.148.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRonen Levy
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-06-21 07:21:58ID requested
12023-05-10 14:24:36announced
22023-11-14 08:47:37announced2023-11-14: Updated project metadata.
Publication List
Levy R, Alter Regev T, Paes W, Gumpert N, Cohen Shvefel S, Bartok O, Dayan-Rubinov M, Alon M, Shmueli MD, Levin Y, Merbl Y, Ternette N, Samuels Y, Large-Scale Immunopeptidome Analysis Reveals Recurrent Posttranslational Splicing of Cancer- and Immune-Associated Genes. Mol Cell Proteomics, 22(4):100519(2023) [pubmed]
Keyword List
submitter keyword: Human, LC-MSMS, Melanoma
Contact List
Yardena Samuels
contact affiliationDepartment of Molecular Cell Biology The Weizmann Institute of Science Rehovot, Israel
contact emailYardena.Samuels@weizmann.ac.il
lab head
Ronen Levy
contact affiliationWeizmann institue
contact emailronen.levy@weizmann.ac.il
dataset submitter
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Dataset FTP location
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