PXD034717

PXD034717 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway
Description	In this study, we found that CB inhibited ICC cell proliferation and promoted cell apoptosis. By using phosphoproteomics, we found significant changes in the proteome and phosphorylome associated with DNA damage and apoptosis in response to CB treatment. Further investigations demonstrated that CB induced ICC cell apoptosis by activating the ATM/CHK2/p53 signaling pathway and upregulating the expression of Fas, DR4 and DR5. Our results collectively indicate that CB may serve as a potential anti-cholangiocarcinoma drug
HostingRepository	iProX
AnnounceDate	2022-06-20
AnnouncementXML	Submission_2023-12-06_20:17:06.612.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wenbo Meng
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-20 04:43:34	ID requested
1	2022-06-20 04:43:40	announced
⏵ 2	2023-12-06 20:17:07	announced	2023-12-07: Update publication.

Xia Z, Li M, Hu M, Lin Y, Atteh LL, Fu W, Gao L, Bai M, Huang C, Yue P, Liu Y, Meng W, Phosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway. Front Oncol, 12():982961(2022) [pubmed]

submitter keyword: Phosphoproteomics

Wenbo Meng
contact affiliation	The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
contact email	mengwb@lzu.edu.cn
lab head
Wenbo Meng
contact affiliation	The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
contact email	mengwb@lzu.edu.cn
dataset submitter

iProX dataset URI