PXD034711
PXD034711 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Aspirin-acetylated SIRT1 induces apoptosis and modulates healthy aging |
| Description | Aspirin or cellular acetyl-CoA could directly acetylate proteins to affect diversity functions. We identify HDACs could be the directly acetylated substrates of aspirin. The inside functional lysine of SIRT1 could be acetylated by aspirin or acetyl-CoA but not be deacetylated by active SIRT1. This irreversible acetylation of SIRT1 inhibits its activity and regulates healthy aging in C. elegans. |
| HostingRepository | iProX |
| AnnounceDate | 2022-06-20 |
| AnnouncementXML | Submission_2022-06-20_01:33:55.353.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhen Wu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | acetylated residue; acetate labeling reagent (N-term) (heavy form, +3amu); S-carboxamidoethyl-L-cysteine; methionine oxidation with neutral loss of 64 Da |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-06-20 01:33:43 | ID requested | |
| ⏵ 1 | 2022-06-20 01:33:55 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Aspirin, SIRT1, Acetylome |
Contact List
| Wei Yu | |
|---|---|
| contact affiliation | State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University |
| contact email | yuw@fudan.edu.cn |
| lab head | |
| Zhen Wu | |
| contact affiliation | Fudan University |
| contact email | wuz16@fudan.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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