PXD034707

PXD034707 is an original dataset announced via ProteomeXchange.

Title	Dynamic changes of the gut microbiota within a new Alzheimer’s Disease rat model using multi-omics approaches
Description	We collected 19 colon content samples from wild-type and new AD models (AppNL-G-F rats) at 3 and 12 months of age and profiled the composition and functionality of gut microbiota using multi-omics approaches. Using the newly emerged proteomics method, data-independent acquisition (DIA), integrated with a sample-matched database, we detected the significantly differentially expressed microbial proteins and observed the functional alterations of gut microbiota at gene ontology (GO), Enzyme Commission (EC) and Clusters of orthologous groups (COG) levels. Our multi-omics study provided a more detailed comprehensive picture of the dynamic gut microbiota at the over-all molecular level.
HostingRepository	iProX
AnnounceDate	2022-06-20
AnnouncementXML	Submission_2023-06-14_19:17:32.489.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	shuaixin Gao
SpeciesList	scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-20 01:10:58	ID requested
⏵ 1	2023-06-14 19:17:32	announced

Dataset with its publication pending

submitter keyword: Gut microbiota, Alzheimer’s disease, Metaproteomics

Catherine C. L. Wong
contact affiliation	Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University
contact email	catclw321@126.com
lab head
shuaixin Gao
contact affiliation	Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University
contact email	gaoshuaixin@126.com
dataset submitter

iProX dataset URI