PXD034706

PXD034706 is an original dataset announced via ProteomeXchange.

Title	Immune Responses to multi-frequency of 1.5GHz and 4.3GHz microwave exposure in rats
Description	In this study, we exposed the rats to 1.5 GHz (L10), 4.3 GHz (C10) or multi-frequency (LC10) microwave at an av-erage power density of 10 mW/cm2. Both single and multi-frequency microwave induced slight pathological changes in thymus and spleen. And, the white blood cells (WBCs) and lymphocytes in peripheral blood were decreased at 6 h and 7 d after exposure, suggesting immune suppressive responses were induced. Among lymphocytes, the B lymphocytes were increased while the T lymphocytes were decreased at 7 d after exposure in C10 and LC10 groups, but not in L10 group. Moreover, multi-frequency microwave regulated the B and T lymphocytes stronger than C band microwave. The results of proteomics showed that both single and mul-ti-frequency microwave regulated numerous genes associated with immune regulation and cel-lular metabolism in peripheral blood and spleen. However, multi-frequency microwave altered the expression of much more proteins. Moreover, multi-frequency microwave down-regulated T lymphocytes development, differentiation and activation associated proteins, while up-regulated B lymphocytes activation related proteins. In conclusion, multi-frequency mi-crowave of 1.5 GHz and 4.3 GHz produced immune suppressive responses via regulating im-mune regulation and cellular metabolism associated proteins. Our findings provided meaningful information for exploring potential mechanisms underlying multi-frequency induced immune suppression.
HostingRepository	iProX
AnnounceDate	2022-06-20
AnnouncementXML	Submission_2022-09-21_23:09:58.655.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Li Zhao
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion; Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-20 00:55:20	ID requested
⏵ 1	2022-09-21 23:09:59	announced

Zhao L, Yao C, Wang H, Dong J, Zhang J, Xu X, Wang H, Yao B, Ren K, Sun L, Peng R, Immune Responses to Multi-Frequencies of 1.5 GHz and 4.3 GHz Microwave Exposure in Rats: Transcriptomic and Proteomic Analysis. Int J Mol Sci, 23(13):(2022) [pubmed]

submitter keyword: microwave, radiation, immune response, proteomic

Ruiyun Peng
contact affiliation	Beijing Institute of Radiation Medicine
contact email	ruiyunpeng18@126.com
lab head
Li Zhao
contact affiliation	Beijing Institute of Radiation Medicine
contact email	lillyliz@163.com
dataset submitter

iProX dataset URI