PXD034654

PXD034654 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The proteomic changes in MCF-7 cells in exposure to cytotoxin
Description	In this study, the proteomic changes of MCF-7 cells exposed to different concentrations of cytotoxin were investigated. At different time points, differentially expressed protein families were detected in MCF-7 cells exposed to cytotoxin. At 8 h, the cytotoxin effects mainly associate with the interference of cell cycle and different intracellular pathways. Among these differentially expressed proteins, pro-apoptotic proteins were also highly expressed. At 24 h, it appeared that cytotoxin induced cell death in MCF-7 cells by involving various cell death pathways.
HostingRepository	PRIDE
AnnounceDate	2026-07-13
AnnouncementXML	Submission_2026-07-12_23:05:29.681.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michelle Yap
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	6550 iFunnel Q-TOF LC/MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-19 05:18:18	ID requested
⏵ 1	2026-07-12 23:05:30	announced

Publication List

D Silva MJ, Yap MKK, Whole-cell proteome decomposition and multiplex proteins arrays reveals alteration of apoptosis-associated proteins interactome following cobra venom cytotoxin exposure. Toxicon, 281():109211(2026) [pubmed]
10.1016/j.toxicon.2026.109211;

D Silva MJ, Yap MKK, Whole-cell proteome decomposition and multiplex proteins arrays reveals alteration of apoptosis-associated proteins interactome following cobra venom cytotoxin exposure. Toxicon, 281():109211(2026) [pubmed]

10.1016/j.toxicon.2026.109211;

Keyword List

submitter keyword: LC-MS/MS, label-free quantitative

submitter keyword: LC-MS/MS, label-free quantitative

Contact List

Dr. Michelle Yap
contact affiliation	School of Science, Monash University Malaysia
contact email	yap.michelle@monash.edu
lab head
Michelle Yap
contact affiliation	Monash University
contact email	yap.michelle@monash.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD034654
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD034654

PRIDE project URI

Repository Record List

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