PXD034643

PXD034643 is an original dataset announced via ProteomeXchange.

Title	(Phospho)proteomics profiling of pre-treatment HER2+ BC biopsies
Description	In this study, we perform (phospho)proteomics analysis of 45 pre-treatment HER2+ needle biopsies of early-stage invasive breast cancer to identify molecular signatures predictive of treatment response to Trastuzumab, Pertuzumab and chemotherapy. All patient biopsies included in this study were classified as HER2+ with a minimum tumour grade of two and tumour cell density of 60% or higher. After needle biopsies were taken, patients completed multiple drug treatment cycles according to the regime of the TRAIN2 study. Finally, treatment response was determined at surgery. The systemic treatment response was categorised as pathological complete response (pCR = ypT0/isypN0) (n=26), near pCR (npCR) (n=8), or No pCR (n=11).
HostingRepository	PRIDE
AnnounceDate	2023-09-20
AnnouncementXML	Submission_2023-09-20_08:54:22.965.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Donna OliviaDebets
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-19 04:47:42	ID requested
⏵ 1	2023-09-20 08:54:23	announced

Dataset with its publication pending

submitter keyword: breast cancer, TMT, treatment resistance,human

MaartenAltelaar
contact affiliation	Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, 3584 CH Utrecht, Netherlands.
contact email	m.altelaar@uu.nl
lab head
Donna OliviaDebets
contact affiliation	Utrecht University
contact email	d.o.debets@uu.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD034643

PRIDE project URI

• PRIDE
  1. PXD034643
     1. Label: PRIDE project
     2. Name: (Phospho)proteomics profiling of pre-treatment HER2+ BC biopsies