PXD034625

PXD034625 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Semaglutide exerts stronger cardioprotective effects than caloric restriction in mice with HFpEF
Description	Patients with heart failure with preserved ejection fraction (HFpEF) often have an unfavorable cardiometabolic profile, and obesity-related HFpEF has become a well-recognized HFpEF sub-phenotype. Targeting this unfavorable cardiometabolic profile may therefore represent a rational treatment strategy. The glucagon-like peptide-1 receptor agonist (GLP1-RA) semaglutide has been shown to induce significant weight loss and to improve cardiovascular outcomes. In this study, we investigated the cardiometabolic effects of semaglutide in a representative mouse model of HFpEF and compared it to the effects of weight loss by caloric restriction.
HostingRepository	PRIDE
AnnounceDate	2024-01-26
AnnouncementXML	Submission_2024-01-26_11:15:47.449.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christian Madsen
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF; Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-17 08:05:36	ID requested
⏵ 1	2024-01-26 11:15:49	announced

Publication List

10.1016/j.jacbts.2023.05.012;
Withaar C, Meems LMG, Nollet EE, Schouten EM, Schroeder MA, Knudsen LB, Niss K, Madsen CT, Hoegl A, Mazzoni G, van der Velden J, Lam CSP, Sillj, é HHW, de Boer RA, The Cardioprotective Effects of Semaglutide Exceed Those of Dietary Weight Loss in Mice With HFpEF. JACC Basic Transl Sci, 8(10):1298-1314(2023) [pubmed]

10.1016/j.jacbts.2023.05.012;

Withaar C, Meems LMG, Nollet EE, Schouten EM, Schroeder MA, Knudsen LB, Niss K, Madsen CT, Hoegl A, Mazzoni G, van der Velden J, Lam CSP, Sillj, é HHW, de Boer RA, The Cardioprotective Effects of Semaglutide Exceed Those of Dietary Weight Loss in Mice With HFpEF. JACC Basic Transl Sci, 8(10):1298-1314(2023) [pubmed]

Keyword List

submitter keyword: HFpEF,Plasma, Heart, Proteomics, cardioprotection, Semaglutide

submitter keyword: HFpEF,Plasma, Heart, Proteomics, cardioprotection, Semaglutide

Contact List

Rudolf A. de Boer
contact affiliation	University of Groningen, University Medical Center Groningen, Department of Cardiology, The Netherlands, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands
contact email	r.a.de.boer@umcg.nl
lab head
Christian Madsen
contact affiliation	Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark.
contact email	ctom@novonordisk.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD034625
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD034625

PRIDE project URI

Repository Record List

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