PXD034616
PXD034616 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A Proximity Labeling-based Orthogonal Trap Approach for Screening HDAC8 substrates |
| Description | We report a proximity labeling-based orthogonal trap approach for investigation of HDAC8 substrates in living cells. In this strategy, the genetic fusions that coupled the engineering enzyme APEX2 with HDAC8 are designed to trap substrate proteins in cellular context, by which they contribute to the covalent tagging of the transient neighboring binders. The tagged proteins are then employed with an integrated orthogonal enrichment strategy that allows for direct identification of acetylated sites on targets. |
| HostingRepository | iProX |
| AnnounceDate | 2022-06-17 |
| AnnouncementXML | Submission_2022-06-16_20:34:51.947.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yepei Huang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-06-16 20:34:41 | ID requested | |
| ⏵ 1 | 2022-06-16 20:34:52 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Histone deacetylase, lysine acetylation, proximity labeling, quantitative proteomics |
Contact List
| Kai Zhang | |
|---|---|
| contact affiliation | Tianjin Medical University |
| contact email | kaizhang@tmu.edu.cn |
| lab head | |
| Yepei Huang | |
| contact affiliation | Tianjin Medical University |
| contact email | huangyepei@tmu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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