PXD034613

PXD034613 is an original dataset announced via ProteomeXchange.

Title	Effect of selenium treatment on central insulin sensitivity: a proteomic analysis in APP/PS1 transgenic mice
Description	Prior studies have demonstrated a closed association between brain insulin resistance and Alzheimer’s disease (AD), while selenium supplementation was shown to improve insulin homeostasis in AD patients and to exert neuroprotective effects in a mouse model of AD. But the mechanisms underlying the neuroprotective actions of selenium remain incompletely understood. In this study we performed a label-free LC-MS/MS quantitative proteomics approach to analyze differentially expressed proteins (DEPs) in the hippocampus and cerebral cortex of APP/PS1 mice following 2 months of treatment with sodium selenate.
HostingRepository	iProX
AnnounceDate	2022-06-16
AnnouncementXML	Submission_2022-09-27_21:09:28.489.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shudong Liu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-16 18:40:56	ID requested
⏵ 1	2022-09-27 21:09:29	announced

Xu X, Qi P, Zhang Y, Sun H, Yan Y, Sun W, Liu S, -Amyloid Precursor Protein/Presenilin-1 Transgenic Mice. Front Mol Neurosci, 15():931788(2022) [pubmed]

submitter keyword: Alzheimer’s disease (AD), Selenium, Insulin sensitivity;

Wenxiu Sun
contact affiliation	Taishan Vocational college of Nursing
contact email	sdwenxiu@163.com
lab head
Shudong Liu
contact affiliation	shandong rongjun general hospital
contact email	lsd008@126.com
dataset submitter

iProX dataset URI