PXD034608

PXD034608 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Combined Effects of Multiple Stresses on Pancreatic Human Islet β-Cell Response: New Insights into the Pathways Involved
Description	This study used multiple common chemical stresses in human islets, mimicking the conditions experienced by dysfunctional β-cells. Proteomic alterations upon exposure of human islets to these stressors were profiled with TMT-based quantitative proteomics and further verified using label-free quantitative proteomics. The differentially expressed proteins under stress conditions were selected for in-depth bioinformatic analysis.
HostingRepository	PRIDE
AnnounceDate	2024-01-26
AnnouncementXML	Submission_2024-01-26_08:11:31.484.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mehari Weldemariam
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-16 03:57:20	ID requested
⏵ 1	2024-01-26 08:11:32	announced

Publication List

Weldemariam MM, Sudhir PR, Woo J, Zhang Q, Effects of multiple stressors on pancreatic human islets proteome reveal new insights into the pathways involved. Proteomics, 23(19):e2300022(2023) [pubmed]
10.1002/pmic.202300022;

Weldemariam MM, Sudhir PR, Woo J, Zhang Q, Effects of multiple stressors on pancreatic human islets proteome reveal new insights into the pathways involved. Proteomics, 23(19):e2300022(2023) [pubmed]

10.1002/pmic.202300022;

Keyword List

submitter keyword: Thapsigargin, Rotenone, TMTpro quantitative proteomics, Glucose, Cytokine,Endoplasmic reticulum (ER) stress
Mitochondria stress
Human islet

submitter keyword: Thapsigargin, Rotenone, TMTpro quantitative proteomics, Glucose, Cytokine,Endoplasmic reticulum (ER) stress

Mitochondria stress

Human islet

Contact List

Qibin Zhang
contact affiliation	Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, North Carolina 27402, United States; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 28081, United States
contact email	q_zhang2@uncg.edu
lab head
Mehari Weldemariam
contact affiliation	The University of North Carolina at Greensboro
contact email	mmweldem@uncg.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD034608
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD034608

PRIDE project URI

Repository Record List

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