PXD034594 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Profiling of mouse brain acetylome and proteome |
Description | Nε-Lysine acetylation is a reversible post-translational protein modification (PTM). In recent years, genetic analysis and animal model studies have shown that protein acetylation is closely related to the development of the nervous system and neurodegenerative diseases such as PD and AD. Here, we aim to profile the mouse brain acetylome by using FSAP, immunoaffinity precipitation of acetylpeptides and mass spectrometry method. We identified 1,591 acetylated proteins containing 4,182 acetylation modification sites in C57BL/6 mice brain. These proteins were involved in myelin sheath, mitochondrial inner membrane and neuron synapse. While KEGG enrichment analysis indicated that these proteins are associated with neurological diseases, such as Alzheimer's disease and Huntington disease. Taken together, we provided a comprehensive profile and clues for understanding the role of acetylated proteins in neuropathology such as neurogenesis, degeneration and aging. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_07:57:32.936.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yuhua JI |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | acetylated residue |
Instrument | Orbitrap Fusion Lumos; TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-06-16 03:37:27 | ID requested | |
1 | 2022-10-13 19:33:07 | announced | |
⏵ 2 | 2023-11-14 07:57:36 | announced | 2023-11-14: Updated project metadata. |
Publication List
Ji Y, Chen Z, Cen Z, Ye Y, Li S, Lu X, Shao Q, Wang D, Ji J, Ji Q, A comprehensive mouse brain acetylome-the cellular-specific distribution of acetylated brain proteins. Front Cell Neurosci, 16():980815(2022) [pubmed] |
Keyword List
submitter keyword: Brain |
acetylome |
mouse |
Contact List
Yuhua Ji |
contact affiliation | Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China. |
contact email | tjiyuhua@126.com |
lab head | |
Yuhua JI |
contact affiliation | Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China. |
contact email | tjiyuhua@126.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD034594
- Label: PRIDE project
- Name: Profiling of mouse brain acetylome and proteome