PXD034538

PXD034538 is an original dataset announced via ProteomeXchange.

Title	The choice of feed composition exerts a considerable influence on phenotypic, metabolic and proteomic outcome in BL/6 male mice
Description	The multitude of obesogenic diets used in rodent studies is enormous and thus hardly manageable. Since standardization is missing and it is presumed that individual compositions provoke individual effects, the choice of quality, quantity and combination of diet ingredients seems to be crucial for the outcome and interpretation of obesity studies. Therefore, the present study was conducted to compare the effects of three commonly used obesogenic diets on selected parameters. Besides basic phenotypic and metabolic characterization, one main aspect was a comparative liver proteome analysis. As expected, the obtained results picture differentiated consequences mainly depending on fat source and/or fat- and sugar quantity. By confirming the general presumption that the choice of nutritional composition is a pivotal factor, the present findings demonstrate that a conscious selection is indispensable for obtaining reliable and sound results in obesity research.In conclusion, we strongly recommend a thorough selection of the appropriate obesogenic diet prior to an experiment and in consideration of the individual research question.
HostingRepository	PRIDE
AnnounceDate	2023-02-09
AnnouncementXML	Submission_2023-02-09_05:57:14.152.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	PreranaWagle
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-15 05:14:31	ID requested
⏵ 1	2023-02-09 05:57:14	announced

Dataset with its publication pending

submitter keyword: FT Liver

RuthJanoschek
contact affiliation	Forschungslabor Fetale Programmierung, Klinik und Poliklinik für Kinder- und Jugendmedizin, Uniklinik Köln, Gebäude 44a, Robert-Koch Str. 16, 50931 Köln
contact email	ruth.janoschek@uk-koeln.de
lab head
PreranaWagle
contact affiliation	CECAD Research Center
contact email	proteomics-facility@uni-koeln.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD034538
     1. Label: PRIDE project
     2. Name: The choice of feed composition exerts a considerable influence on phenotypic, metabolic and proteomic outcome in BL/6 male mice