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PXD034526

PXD034526 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia
DescriptionLiver cancer is one of the most common malignant tumors in the world and metastasis is the leading cause of death associated with liver cancer. Hypoxia is a common feature of solid tumors and enhances malignant character of cancer cells. However, the exact mechanisms involved in hypoxia-driven liver cancer progression and metastasis have not been well clarified so far. The aim of this study was to investigate the contribution of long non-coding RNA (lncRNA) in hypoxia promoting liver cancer progression. We screened and revealed LINC00839 as a novel hypoxia-responsive lncRNA in liver cancer. LINC00839 expression was up-regulated in liver cancer tissues and cell lines, and the patients with high LINC00839 expression had shortened overall survival. LINC00839 further overexpressed under hypoxia and promoted liver cancer cell proliferation, migration, and invasion. Mechanistically, LINC00839 bound multiple proteins that were primarily associated with the metabolism and RNA transport, and positively regulated the expression of Formin-like protein 2 (FMNL2). LINC00839 could promote hypoxia-mediated liver cancer progression, suggesting it may be a clinically valuable biomarker and serve as a molecular target for the diagnosis, prognosis, and therapy of liver cancer.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:05:35.567.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMingfen Li
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-06-15 02:33:39ID requested
12023-03-10 18:48:11announced
22023-11-14 08:05:39announced2023-11-14: Updated project metadata.
Publication List
Xie Y, Lin H, Wei W, Kong Y, Fang Q, Chen E, Liu J, Li M, LINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia. Sci Rep, 12(1):18757(2022) [pubmed]
Keyword List
submitter keyword: Liver cancer
Hypoxia
Long non-coding RNA
Formin-like protein 2
Contact List
Yangyi Xie
contact affiliationGuangxi University of Chinese Medicine
contact emaillimf@gxtcmu.edu.cn
lab head
Mingfen Li
contact affiliationGuangxi University of Chinese Medicine
contact emaillimf@gxtcmu.edu.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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