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PXD034456

PXD034456 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSerum metabolomics and proteomics to study the antihyperten-2 sive effect of Tenebrio molitor extracts
DescriptionThis study aimed at integrating metabolomics and proteomics data for a comprehensive view of the molecular targets of intervention of protein extracts from Tenebrio molitor in treating hypertension. Serum samples from spontaneously hypertensive rats and Wistar Kyoto rats were analyzed using a quantitative metabolomics and label-free proteomics approach based on liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS). Among deregulated metabolites and proteins in hypertensive rats, we found 15 metabolites and 17 proteins that were restored by supplementation with Tenebrio molitor protein extract. The combination of metabolomics and proteomics provided useful data to uncover the molecular targets of intervention and the underlying functional mechanism of Tenebrio molitor protein extract in an animal model such as spontaneously hypertensive rats. The results suggested that Tenebrio molitor supplementation could effectively treat hypertension, partially by regulating proteins and molecules mainly involved in biological pathways associated to angiotensinogen-angiotensin, Serin protease inhibitors, kallikrein–kinin, reactive oxygen scavenging, and lipid peroxidation.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_07:27:34.779.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRoberto Stella
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-06-10 02:33:36ID requested
12022-10-13 15:01:37announced
22023-11-14 07:27:35announced2023-11-14: Updated project metadata.
Publication List
Stella R, Peggion C, Bergantin C, Biancotto G, Frosini M, Dreassi E, Marcolongo P, Aloisi AM, Pessina F, . Nutrients, 14(16):(2022) [pubmed]
Keyword List
submitter keyword: functional food
multi-omics
blood pressure
SHR rats
insect protein supplementation
Contact List
Federica Pessina
contact affiliationDepartment of Molecular and Developmental Medicine, University of Siena, Italy
contact emailfederica.pessina@unisi.it
lab head
Roberto Stella
contact affiliationIstituto Zooprofilattico Sperimentale delle Venezie
contact emailrstella@izsvenezie.it
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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