PXD034441

PXD034441 is an original dataset announced via ProteomeXchange.

Title	Subtyping Lewy body disorders using proteomics
Description	Lewy body disorders (LBD), characterized by the deposition of misfolded α-synuclein (α-Syn), are clinically heterogeneous. We hypothesized that this heterogeneity might reflect α-Syn molecular diversity, between both patients and different brain regions. Using an ultra-sensitive assay, we evaluated α-Syn seeding from 30 LBD patients with different clinical phenotypes and disease durations. Interestingly, α-Syn from patients with rapid disease progression (<3 years) had a higher nigral seeding capacity than the rest of the patients included. We performed a proteomic-wide profiling of the substantia nigra from 5 high and 5 low seeder patients. The proteomic data suggests a significant disruption in mitochondrial function and lipid metabolism in high seeder cases compared to the low seeders.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:57:03.590.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD034441
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Ivan Martinez-Valbuena
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-09 15:14:10	ID requested
1	2022-07-20 11:09:43	announced
⏵ 2	2023-11-14 08:57:04	announced	2023-11-14: Updated project metadata.

10.6019/PXD034441;

submitter keyword: Parkinson’s disease,human, substantia nigra

Ivan Martinez
contact affiliation	University of Toronto | U of T · Tanz Centre for Research in Neurodegenerative Diseases
contact email	ivan.martinez@utoronto.ca
lab head
Ivan Martinez-Valbuena
contact affiliation	Tanz Centre for Research in Neurodegenerative Diseases University of Toronto
contact email	ivan.martinez@utoronto.ca
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD034441
     1. Label: PRIDE project
     2. Name: Subtyping Lewy body disorders using proteomics