PXD034438

PXD034438 is an original dataset announced via ProteomeXchange.

Title	Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult – SWATH proteomics
Description	The well-known difference in sensitivity of mice and rats to acetaminophen (APAP) liver injury has been related to differences in the fraction that is bioactivated to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI). Physiologically-based pharmacokinetic modelling was used to identify doses of APAP (300 and 1000 mg/kg in mice and rats, respectively) yielding similar hepatic burdens of NAPQI, to enable the comparison of temporal liver tissue responses under conditions of equivalent chemical insult.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_06:39:26.179.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Giusy Russomanno
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-09 14:45:58	ID requested
1	2023-08-31 10:30:35	announced
⏵ 2	2023-11-14 06:39:26	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

ProteomeXchange project tag: Liver (B/D-HPP), TransQST, Biology/Disease-Driven Human Proteome Project (B/D-HPP)

submitter keyword: Oxidative stress, species differences, SWATH, liver injury, acetaminophen

Ian Copple
contact affiliation	MRC Centre for Drug Safety Science, Department of Pharmacology & Therapeutics, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Liverpool, UK.
contact email	ian.copple@liverpool.ac.uk
lab head
Giusy Russomanno
contact affiliation	University of Liverpool
contact email	Giusy.Russomanno@liverpool.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD034438

PRIDE project URI

• PRIDE
  1. PXD034438
     1. Label: PRIDE project
     2. Name: Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult – SWATH proteomics