PXD034414
PXD034414 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Membrane atg8ylation coordinates stress granule formation and mTOR inactivation in response to lysosomal damage |
Description | We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG) formation and that the process termed membrane atg8ylation coordinates SG formation with mTOR inactivation during lysosomal stress. SGs were induced by lysosome-damaging agents including SARS-CoV-2ORF3a, Mycobacterium tuberculosis, and proteopathic tau. During damage, mammalian ATG8s directly interacted with the core SG proteins NUFIP2 and G3BP1. Atg8ylation was needed for their recruitment to damaged lysosomes independently of SG condensates whereupon NUFIP2 contributed to mTOR inactivation via the Ragulator-RagA/B complex. Thus, cells employ membrane atg8ylation to control and coordinate SG and mTOR responses to lysosomal damage. |
HostingRepository | MassIVE |
AnnounceDate | 2023-01-26 |
AnnouncementXML | Submission_2023-01-26_08:09:59.394.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Brett Phinney |
SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
ModificationList | Oxidation; Carbamidomethyl |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-06-09 12:36:06 | ID requested | |
⏵ 1 | 2023-01-26 08:10:00 | announced |
Publication List
Jia J, Wang F, Bhujabal Z, Peters R, Mudd M, Duque T, Allers L, Javed R, Salemi M, Behrends C, Phinney B, Johansen T, Deretic V, Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage. J Cell Biol, 221(11):(2022) [pubmed] |
Keyword List
submitter keyword: mTOR, lysosomal damage |
Contact List
Vojo Deretic | |
---|---|
contact affiliation | Department of Molecular Genetics and Microbiology University of New Mexico Health Sciences Center |
contact email | vderetic@salud.unm.edu |
lab head | |
Brett Phinney | |
contact affiliation | UC Davis |
contact email | brettsp@ucdavis.edu |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000089622/ |