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PXD034397

PXD034397 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleStructure of Cancer Antigen Mesothelin and Its Complex with Therapeutic Antibodies
DescriptionMesothelin is a differentiation antigen expressed at high levels on the surface of many cancers; its interaction with cancer antigen CA-125 can lead to metastasis. Mesothelin has been the subject of intensive investigations as a potential cancer antigen for immunotherapy. Structures of a fragment of mesothelin, full-length mesothelin alone and in complex with the Fab fragment of the therapeutic antibody MORAb-009, as well as a complex of its C-terminal fragment containing the majority of the identified shedding sites, or the shedding-resistant fragment, with monoclonal antibody 15B6 were obtained. The glycosylation profile of mesothelin purified from A431/H9 cells and patient ascites were obtained by glycoproteomics
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:45:46.067.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAsif Shajahan
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-06-07 01:19:11ID requested
12023-05-10 09:02:07announced
22023-11-14 08:45:46announced2023-11-14: Updated project metadata.
Publication List
Zhan J, Lin D, Watson N, Esser L, Tang WK, Zhang A, Liu X, Hassan R, Gleinich A, Shajahan A, Azadi P, Pastan I, Xia D, Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies. Cancer Res Commun, 3(2):175-191(2023) [pubmed]
Keyword List
submitter keyword: antibody, molecular recognition, cancer marker, mesothelin,Crystal structure
Contact List
Parastoo Azadi
contact affiliationAssociate Director of Analytical Services, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
contact emailazadi@ccrc.uga.edu
lab head
Asif Shajahan
contact affiliationComplex Carbohydrate Research Center
contact emailasifklm@uga.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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