PXD034397 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Structure of Cancer Antigen Mesothelin and Its Complex with Therapeutic Antibodies |
Description | Mesothelin is a differentiation antigen expressed at high levels on the surface of many cancers; its interaction with cancer antigen CA-125 can lead to metastasis. Mesothelin has been the subject of intensive investigations as a potential cancer antigen for immunotherapy. Structures of a fragment of mesothelin, full-length mesothelin alone and in complex with the Fab fragment of the therapeutic antibody MORAb-009, as well as a complex of its C-terminal fragment containing the majority of the identified shedding sites, or the shedding-resistant fragment, with monoclonal antibody 15B6 were obtained. The glycosylation profile of mesothelin purified from A431/H9 cells and patient ascites were obtained by glycoproteomics |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:45:46.067.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Asif Shajahan |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-06-07 01:19:11 | ID requested | |
1 | 2023-05-10 09:02:07 | announced | |
⏵ 2 | 2023-11-14 08:45:46 | announced | 2023-11-14: Updated project metadata. |
Publication List
Zhan J, Lin D, Watson N, Esser L, Tang WK, Zhang A, Liu X, Hassan R, Gleinich A, Shajahan A, Azadi P, Pastan I, Xia D, Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies. Cancer Res Commun, 3(2):175-191(2023) [pubmed] |
Keyword List
submitter keyword: antibody, molecular recognition, cancer marker, mesothelin,Crystal structure |
Contact List
Parastoo Azadi |
contact affiliation | Associate Director of Analytical Services, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA |
contact email | azadi@ccrc.uga.edu |
lab head | |
Asif Shajahan |
contact affiliation | Complex Carbohydrate Research Center |
contact email | asifklm@uga.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD034397
- Label: PRIDE project
- Name: Structure of Cancer Antigen Mesothelin and Its Complex with Therapeutic Antibodies