PXD034397

PXD034397 is an original dataset announced via ProteomeXchange.

Title	Structure of Cancer Antigen Mesothelin and Its Complex with Therapeutic Antibodies
Description	Mesothelin is a differentiation antigen expressed at high levels on the surface of many cancers; its interaction with cancer antigen CA-125 can lead to metastasis. Mesothelin has been the subject of intensive investigations as a potential cancer antigen for immunotherapy. Structures of a fragment of mesothelin, full-length mesothelin alone and in complex with the Fab fragment of the therapeutic antibody MORAb-009, as well as a complex of its C-terminal fragment containing the majority of the identified shedding sites, or the shedding-resistant fragment, with monoclonal antibody 15B6 were obtained. The glycosylation profile of mesothelin purified from A431/H9 cells and patient ascites were obtained by glycoproteomics
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:45:46.067.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Asif Shajahan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-07 01:19:11	ID requested
1	2023-05-10 09:02:07	announced
⏵ 2	2023-11-14 08:45:46	announced	2023-11-14: Updated project metadata.

Zhan J, Lin D, Watson N, Esser L, Tang WK, Zhang A, Liu X, Hassan R, Gleinich A, Shajahan A, Azadi P, Pastan I, Xia D, Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies. Cancer Res Commun, 3(2):175-191(2023) [pubmed]

submitter keyword: antibody, molecular recognition, cancer marker, mesothelin,Crystal structure

Parastoo Azadi
contact affiliation	Associate Director of Analytical Services, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
contact email	azadi@ccrc.uga.edu
lab head
Asif Shajahan
contact affiliation	Complex Carbohydrate Research Center
contact email	asifklm@uga.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD034397

PRIDE project URI

• PRIDE
  1. PXD034397
     1. Label: PRIDE project
     2. Name: Structure of Cancer Antigen Mesothelin and Its Complex with Therapeutic Antibodies