PXD034375

PXD034375 is an original dataset announced via ProteomeXchange.

Title	Raw data for mass spectrometry analysis of the effects of hypoxia on mitochondrial protein composition
Description	This project wanted to demonstrate that mitoselfphagy degrades various mitochondrial proteins to a different extent. Therefore，we measured the levels of mitochondrial proteins under hypoxia by mass spectrometry analysis. After 24 hours of hypoxia, most mitochondrial proteins, locating at different mitochondrial compartments, were decreased to different extents relative to normoxic controls. After hypoxia, The certain mitochondrial proteins were increased, and some mitochondrial proteins remained almost unchanged. These data demonstrated that mitoselfphagy is different from traditional mitophagy that degrades the entire mitochondria, which degrades various mitochondrial proteins to a different extent.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:06:36.898.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tianshu Hao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-06 07:19:34	ID requested
1	2023-10-24 10:28:37	announced
⏵ 2	2023-11-14 09:06:39	announced	2023-11-14: Updated project metadata.

Hao T, Yu J, Wu Z, Jiang J, Gong L, Wang B, Guo H, Zhao H, Lu B, Engelender S, He H, Song Z, Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion. Nat Commun, 14(1):4105(2023) [pubmed]

submitter keyword: LC-MSMS, HeLa cell, mitochondria fraction,human

Zhiyin Song
contact affiliation	College of Life Sciences, Wuhan Univeristyege of Life Sciences, Wuhan Univeristylege of Life Sciences, Wuhan Univeristy
contact email	songzy@whu.edu.cn
lab head
Tianshu Hao
contact affiliation	Wuhan University
contact email	haotianshu@whu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD034375

PRIDE project URI

• PRIDE
  1. PXD034375
     1. Label: PRIDE project
     2. Name: Raw data for mass spectrometry analysis of the effects of hypoxia on mitochondrial protein composition