PXD034374

PXD034374 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Utilizing HXMS to Uncover Structural Basis of CPC Phase Separation
Description	The centromere is the locus that directs accurate chromosome segregation, and a mater regulatory complex ,the chromosome passenger comlex (CPC) is enriched in a region of the mitotic centromre termed the inner centromre. Recent findings support a role of CPC phase separation in its localization and function in mitotic error correction. Currently there are no teqhniques to globaly map the motifs on proteins that drive the multivalent interactions. In this context, we now employ hydrogen/deuterium exchange coupled to mass spectrometry (HXMS) to study dynamics of CPC phase separation.
HostingRepository	PRIDE
AnnounceDate	2024-03-13
AnnouncementXML	Submission_2024-03-12_19:10:50.879.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nikaela W. Bryan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-06 06:41:01	ID requested
⏵ 1	2024-03-12 19:10:51	announced

Publication List

10.7554/ELIFE.92709;

10.7554/ELIFE.92709;

Keyword List

submitter keyword: Phase Separation,HXMS, LCMS

submitter keyword: Phase Separation,HXMS, LCMS

Contact List

Ben E. Black
contact affiliation	Department of Biochemistry and Biophysics, University of Pennsylvania
contact email	blackbe@pennmedicine.upenn.edu
lab head
Nikaela W. Bryan
contact affiliation	University of Pennsylvania
contact email	nikaelab@pennmedicine.upenn.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/03/PXD034374
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/03/PXD034374

PRIDE project URI

Repository Record List

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