PXD034339
PXD034339 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | ISX-9 potentiates CaMKIIδ-mediated BMAL1 activation to enhance circadian amplitude |
| Description | Circadian dysregulation associates with numerous diseases including metabolic dysfunction, sleep disorder, depression and aging. Given that declined circadian amplitude is a trait commonly found with compromised health, interventions that design in precluding circadian amplitude from dampening will aid to mitigate complex, circadian-related diseases. Here we identify a neurogenic small molecule ISX-9 that is able to support persistent and higher amplitude of circadian oscillations. ISX-9 improves diurnal metabolic rhythms in middle-aged mice. Moreover, the ISX-9-treated mice show better sleep homeostasis with increased delta power during the day time and higher locomotive activity in the dark period. ISX-9 augments CaMKIIδ expression and increases BMAL1 activity via eliciting CaMKIIδ-mediated phosphorylation on BMAL1 residues S513/S515/S516, accordingly composes a positive feedback effect on enhancing circadian amplitude. CaMKIIδ-targeting, and the use of ISX-9 may serve as decent choices for treating circadian-related disorders. |
| HostingRepository | iProX |
| AnnounceDate | 2022-06-06 |
| AnnouncementXML | Submission_2022-11-01_20:09:16.136.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jiali Ou |
| SpeciesList | scientific name: Mus |
| ModificationList | phosphorylated residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-06-06 01:53:21 | ID requested | |
| ⏵ 1 | 2022-11-01 20:09:16 | announced |
Publication List
| Li H, Ou J, Li Y, Xu N, Li Q, Wu P, Peng C, Tang YC, Chang HC, -mediated BMAL1 activation to enhance circadian amplitude. Commun Biol, 5(1):750(2022) [pubmed] |
Keyword List
| submitter keyword: ISX-9, BMAL1, circadian, CaMKIIδ |
Contact List
| Yun-Chi Tang | |
|---|---|
| contact affiliation | shanghai institute of nutrition and health |
| contact email | yctang@sibs.ac.cn |
| lab head | |
| Jiali Ou | |
| contact affiliation | Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences |
| contact email | oujiali2019@sibs.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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