PXD034328

PXD034328 is an original dataset announced via ProteomeXchange.

Title	Proteomic modifications associated with obesity and periodontitis: longitudinal comparation in women during pregnancy and after delivery
Description	Aim: This study aimed to analyze the salivary proteomic profile related to obesity and periodontitis in women during pregnancy and after delivery. Materials and methods: The sample assisted during the 3rd trimester of pregnancy (T1) and after childbirth (T2) was divided into: with obesity and periodontitis (OP = 8); with obesity and without periodontitis (OWP = 10); with normal BMI but with periodontitis (NP = 10); with normal BMI and without periodontitis (NWP = 10). The proteins were extracted and processed individually by label-free proteomics (nLC-ESI-MS/MS). ProteinLynx GlobalServer software was used to process and search the data, and the proteins were analyzed by their access number by UniProt catalog. Results: The up-regulation of Heat shock protein (HSP) 70 kDa 1A, 1B and 1-like were related to both obesity and periodontitis, separately. Albumin and thioredoxin were up-expressed in periodontitis cases, while Cystatins (mainly S, SA, SN) and Lactotransferrin were down-expressed. The high abundance of Submaxillary gland androgen-regulated protein 3B, S100A8, Matrix metalloproteinase-9 (MMP9), HSP 70 kDa 2 and 6, Putative HSP 70 kDa 7, HSP 71 kDa, Haptoglobin and Plastin-1 were significant in the combination of obesity and periodontitis. Conclusion: Obesity and periodontitis remarkably altered the proteome of the saliva during pregnancy with substantial alterations after delivery. Proteins related to humoral immune response and antibacterial humoral response were highly expressed in women with periodontitis, while proteins related to glycolytic, carbohydrate catabolic, glucose metabolic, organophosphate metabolic and carbohydrate derivative metabolic processes were more expressed in individuals with obesity.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:14:33.063.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gerson Foratori Junior
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Xevo G2 Q-Tof; nanoACQUITY UPLC

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-06 01:08:17	ID requested
1	2023-02-23 04:45:49	announced
⏵ 2	2023-11-14 08:14:34	announced	2023-11-14: Updated project metadata.

Foratori-Junior GA, Ventura TMO, Grizzo LT, Carpenter GH, Buzalaf MAR, Sales-Peres SHC, Label-Free Quantitative Proteomic Analysis Reveals Inflammatory Pattern Associated with Obesity and Periodontitis in Pregnant Women. Metabolites, 12(11):(2022) [pubmed]

submitter keyword: Obesity, Saliva, Pregnancy, Proteomics, Periodontitis

Gerson Aparecido Foratori Junior
contact affiliation	Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil
contact email	gerson.foratori@usp.br
lab head
Gerson Foratori Junior
contact affiliation	Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo
contact email	gerson.foratori@usp.br
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD034328
     1. Label: PRIDE project
     2. Name: Proteomic modifications associated with obesity and periodontitis: longitudinal comparation in women during pregnancy and after delivery