PXD034276

PXD034276 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Inhibition of L-type amino acid transporter 1 induces disruption of cancer amino acid homeostasis with altered cellular signals
Description	This study characterized the changes of phosphorylation signaling cascades induced by LAT1 inhibition in three cell lines of biliary tract cancer treated with LAT1 specific inhibitor JPH203 for 15 and 30 min. Immobilized metal affinity chromatography and liquid chromatography-tandem mass spectrometry with MS2-based quantitation of tandem mass tag were utilized.
HostingRepository	jPOST
AnnounceDate	2023-05-24
AnnouncementXML	Submission_2023-05-24_01:26:56.362.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD034276
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Hiroki
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; TMT6plex reporter+balance reagent N-acylated residue; TMT6plex reporter+balance reagent acylated N-terminal; O-phospho-L-serine; O-phospho-L-threonine; O4'-phospho-L-tyrosine; deamidated L-glutamine; deamidated L-asparagine
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-05 04:05:00	ID requested
⏵ 1	2023-05-24 01:26:57	announced

Publication List

Okanishi H, Ohgaki R, Xu M, Endou H, Kanai Y, Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of L-type amino acid transporter 1. Cancer Metab, 10(1):18(2022) [pubmed]

Okanishi H, Ohgaki R, Xu M, Endou H, Kanai Y, Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of L-type amino acid transporter 1. Cancer Metab, 10(1):18(2022) [pubmed]

Keyword List

submitter keyword: human, LAT1, JPH203, IMAC

submitter keyword: human, LAT1, JPH203, IMAC

Contact List

Yoshikatsu Kanai
lab head
Hiroki
contact affiliation	Okanishi
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST001655/