PXD034263
PXD034263 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comprehensive molecular characterization of clinical responses to PD-1 inhibition in hepatocellular carcinoma |
Description | Hepatocellular carcinoma (HCC) is the sixth most common cancer and the fourth lethal cancer worldwide. We performed proteomic and metabolomic profiling of sera from 67 HCC patients who received pembrolizumab therapy and 15 healthy individuals. We then trained a machine learning model using proteomic and metabolomic measurements from a training cohort containing 26 patients with resistance to PD-1 treatment and 23 patients with response to PD-1 treatment. The model was validated using a testing cohort containing 7 patients with resistance to PD-1 treatment and 6 patients with response to PD-1 treatment, 12 of which were correctly classified. Our analysis reveals the proteomic and metabolic features of HCC patients which correlated with PD1 antibody therapy and provide serum predictive markers for selection of patients with potential response to PD1 therapy. |
HostingRepository | iProX |
AnnounceDate | 2022-06-02 |
AnnouncementXML | Submission_2022-06-01_20:50:02.600.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jian-Hang Huang |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-06-01 20:49:46 | ID requested | |
⏵ 1 | 2022-06-01 20:50:02 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: hepatocellular carcinoma, immunotherapy, PD-1, Proteomics, Metabolomics, machine learning, random forest |
Contact List
Feng Liu | |
---|---|
contact affiliation | Fudan University Institutes of Biomedical Sciences |
contact email | liuf@fudan.edu.cn |
lab head | |
Jian-Hang Huang | |
contact affiliation | Fudan University Institutes of Biomedical Sciences |
contact email | mzbj1996@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |