PXD034258

PXD034258 is an original dataset announced via ProteomeXchange.

Title	Protein Profiling of human iPSC-derived cardiomyocytes with mutations in ACTN2
Description	Genetic variants in α-actinin 2 (ACTN2) are associated with several forms of (cardio)myopathy. Here, we analyzed the proteome of 2D and EHT cultured cardiomyocytes derived from mutant-expressing (ACTN2mut) and a wild-type-expressing (ACTN2wt) hiPSC lines, both created with CRISPR/Cas9 genetic tools.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:25:04.507.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Elke Hammer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-01 11:21:32	ID requested
1	2022-10-13 10:12:00	announced
⏵ 2	2023-11-14 08:25:06	announced	2023-11-14: Updated project metadata.

Zech ATL, Prondzynski M, Singh SR, Pietsch N, Orthey E, Alizoti E, Busch J, Madsen A, Behrens CS, Meyer-Jens M, Mearini G, Lemoine MD, Kr, ä, mer E, Mosqueira D, Virdi S, Indenbirken D, Depke M, Salazar MG, V, ö, lker U, Braren I, Pu WT, Eschenhagen T, Hammer E, Schlossarek S, Carrier L, Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes. Cells, 11(17):(2022) [pubmed]

submitter keyword: 2D, DIA,human, engineered heart tissue (EHT), iPSC-derived cardiomyocytes

Dr. Elke Hammer
contact affiliation	Dr. Elke Hammer Universitätsmedizin Greifswald Interfakultäres Institut für Genetik und Funktionelle Genomforschung Abteilung für Funktionelle Genomforschung Felix-Hausdorff-Straße 8 17487 Greifswald
contact email	hammer@uni-greifswald.de
lab head
Elke Hammer
contact affiliation	Dept. of Functional Genomics
contact email	hammer@uni-greifswald.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD034258

PRIDE project URI

• PRIDE
  1. PXD034258
     1. Label: PRIDE project
     2. Name: Protein Profiling of human iPSC-derived cardiomyocytes with mutations in ACTN2