PXD034232

PXD034232 is an original dataset announced via ProteomeXchange.

Title	Global-scale profiling of differential expressed lysine lactylated proteins in cerebral endothelium of cerebral ischemia-reperfusion injury rats
Description	(i) The lactylation may play a key role in the process of ischemia-reperfusion injury in rats, and may be achieved by regulating Ca2+signaling pathway. (ii) The key proteins of Ca2+ signaling pathway, Scl25a4 (K245), Slc25a5 (K96) and Vdac1 (K20, K266), are modified by lactation, which may affect mitochondrial apoptosis pathway and mediates neuronal death.
HostingRepository	iProX
AnnounceDate	2022-05-31
AnnouncementXML	Submission_2022-11-02_20:10:48.911.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuan Yao
SpeciesList	scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationList	lactic acid
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-31 18:52:41	ID requested
⏵ 1	2022-11-02 20:10:51	announced

Yao Y, Bade R, Li G, Zhang A, Zhao H, Fan L, Zhu R, Yuan J, Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats. Cell Mol Neurobiol, 43(5):1989-2004(2023) [pubmed]

submitter keyword: Lysine lactylation, PTMs, Cerebral ischemia-reperfusion injury, Ca2+ signaling pathway

Yuan Jun
contact affiliation	Inner Mongolia People`s Hospital
contact email	13947108585@139.com
lab head
Yuan Yao
contact affiliation	Inner Mongolia People`s Hospital
contact email	yuanyao129@imu.edu.cn
dataset submitter

iProX dataset URI