PXD034144

PXD034144 is an original dataset announced via ProteomeXchange.

Title	Role of RNA binding protein PgRBP1 in alteration of protein profile of Porphyromonas gingivalis
Description	The oral periodontal pathogen Porphyromonas gingivalis must adapt to ever changing environment to survive and cause disease. So far most of the efforts concerning the regulatory mechanisms employed by the bacterium centered on DNA-binding regulators. Here we focused on a RNA-binding protein that is indispensable for the bacterium to survive with host cells. We have determined the proteome affected by deletion of the protein, designated here PgRBP1. Three strains were used: WT, PgRBP1-deficient strain designated V3139 and a complemented strain V3236. In total, 1,393 proteins were identified. 592 proteins in the comparison of P. gingivalis 3139 vs. WT, 228 proteins in the comparison of P. gingivalis 3236 vs. WT, and 276 proteins in the comparison of P. gingivalis 3139 vs. 3236 showed differential level with statistical significance
HostingRepository	PRIDE
AnnounceDate	2025-06-02
AnnouncementXML	Submission_2025-06-01_16:03:48.246.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Janina Lewis
SpeciesList	scientific name: Porphyromonas gingivalis (strain ATCC BAA-308 / W83); NCBI TaxID: 242619;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-26 01:32:53	ID requested
⏵ 1	2025-06-01 16:03:49	announced

10.3389/fcimb.2025.1569544;

Yanamandra S, Marsh H, Cvitkovic R, Gui Q, Belvin BR, Lewis JP, RNA-binding protein is required for growth in high levels of zinc and persistence with host cells. Front Cell Infect Microbiol, 15():1569544(2025) [pubmed]

submitter keyword: Porphyromonas gingivalis, Bacteroides, proteomics, RNA binding protein, regulation

Janina P Lewis
contact affiliation	Virginia Commonwealth University Philips Institute for Oral Health Research VCU School of Dentistry Richmond, VA, United States
contact email	jplewis@vcu.edu
lab head
Janina Lewis
contact affiliation	Virginia Commonwealth University
contact email	jplewis@vcu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD034144

PRIDE project URI

• PRIDE
  1. PXD034144
     1. Label: PRIDE project
     2. Name: Role of RNA binding protein PgRBP1 in alteration of protein profile of Porphyromonas gingivalis