PXD034137

PXD034137 is an original dataset announced via ProteomeXchange.

Title	A multi¬omic analysis reveal gender differences in the hippocampus of Alzheimer disease subjects
Description	Alzheimer’s disease (AD) is the most common neurodegenerative pathology affecting more than 20 million people worldwide and the leading cause of dementia. Although AD neuropathology has been well defined, the underlying causes of the disease remain debatable. Recently, sex and gender are emerging as crucial drivers of development and progression of AD dementia. So, to investigate the molecular basis of gender¬related influences on the pathology of AD, we analyzed hippocampal brain tissues from control (CTR) and Alzheimer’s Disease (AD) patients using an integrated proteomic, metabolomics and transcriptomic approach. A principal component analysis carried out to identify major differences among the two datasets highlights differences among AD and CTR. Focusing on the gender dependent omic changes, comparative analyses were carried out considering males (M) and females (F) as separate subgroups in AD patients and in healthy subjects. The analysis was conducted considering proteins differentially expressed if they were present only in one condition or showed significant t¬test difference. The results strongly suggest that there is a significant difference between male and female in all the omic data sets either in the neurodegenerative disease and in the control. Preliminary results from bioinformatics analysis highlight major differences in energetic metabolism, cytoskeleton organization and oxidative stress response.The results are of main relevance for future clinical interventions that can reduce dementia risk in both male and female patients.
HostingRepository	PRIDE
AnnounceDate	2024-10-01
AnnouncementXML	Submission_2024-10-01_04:38:32.966.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Francesca Grassi Scalvini
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-26 01:18:50	ID requested
⏵ 1	2024-10-01 04:38:33	announced

10.1016/J.CELREP.2022.111271;

submitter keyword: Proteomics, nanoLC-MS/MS

Francesca Grassi Scalvini
contact affiliation	DIVAS
contact email	francesca.grassiscalvini@unimi.it
lab head
Francesca Grassi Scalvini
contact affiliation	Università degli studi di Milano
contact email	francesca.grassiscalvini@guest.unimi.it
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD034137
     1. Label: PRIDE project
     2. Name: A multi¬omic analysis reveal gender differences in the hippocampus of Alzheimer disease subjects