PXD034083

PXD034083 is an original dataset announced via ProteomeXchange.

Title	N-glycosylation analysis of human complement component C3 LC-MS
Description	The most abundant and central component, glycoprotein C3, contributes to the development of type 1 diabetes by enhancing the organ-specific autoimmune inflammatory processes. It is known that changes in glycosylation can modulate inflammatory responses and we recently showed that children at the onset of type 1 diabetes have a higher proportion of oligomannose glycans in plasma N-glycome compared to their healthy siblings. Due to fact that C3 contains two N-glycosylation sites occupied by this type of glycans, our aim was to develop a novel high-throughput and cost-effective glycoproteomic workflow for N-glycosylation analysis of human C3 to reveal the possible role of C3 glycosylation in type 1 diabetes development.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:23:47.813.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dinko Šoić
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	maXis

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-25 02:33:38	ID requested
1	2023-03-10 13:34:14	announced
⏵ 2	2023-11-14 08:23:48	announced	2023-11-14: Updated project metadata.

Š, oi, ć D, Keser T, Š, tambuk J, Kifer D, Pociot F, Lauc G, Morahan G, Novokmet M, Gornik O, High-Throughput Human Complement C3 N-Glycoprofiling Identifies Markers of Early Onset Type 1 Diabetes Mellitus in Children. Mol Cell Proteomics, 21(10):100407(2022) [pubmed]

submitter keyword: LC-MS;C3

Olga Gornik
contact affiliation	Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
contact email	ogornik@pharma.hr
lab head
Dinko Šoić
contact affiliation	University of Zagreb Faculty of Pharmacy and Biochemistry
contact email	dsoic@pharma.hr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD034083

PRIDE project URI

• PRIDE
  1. PXD034083
     1. Label: PRIDE project
     2. Name: N-glycosylation analysis of human complement component C3 LC-MS