PXD034073

PXD034073 is an original dataset announced via ProteomeXchange.

Title	Proteomics of Human Hepatoma Huh-7 Cells Treated by Three Multi-RTK Inhibitors
Description	Sorafenib, lenvatinib and regorafenib, the multi-RTK inhibitors with potent anti-angiogenesis effects, are currently therapeutic drugs generally recommended for the patients with advanced hepatocellular carcinoma (HCC). To date, however, there have been no published studies on the mechanism underling differential effects of the three drugs on HCC cell proliferation, and the proteomic analysis in HCC cell lines treated by regorafenib or lenvatinib.The present project for the first time performed a direct comparison of their pharmacological interventions for influencing whole cell proteomics using tandem mass tag-based peptide-labeling technique.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:15:28.770.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dezhi Kong
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-25 02:08:34	ID requested
1	2022-10-13 03:53:28	announced
⏵ 2	2023-11-14 07:15:29	announced	2023-11-14: Updated project metadata.

Ren X, Zhang Q, Guo W, Wang L, Wu T, Zhang W, Liu M, Kong D, Cell-cycle and apoptosis related and proteomics-based signaling pathways of human hepatoma Huh-7 cells treated by three currently used multi-RTK inhibitors. Front Pharmacol, 13():944893(2022) [pubmed]

submitter keyword: Huh-7 Cells, Proteomics, Multi-RTK Inhibitors

Dezhi Kong
contact affiliation	School of Chinese Integrative Medicine, Hebei Medical University, Shijiazhuang, China
contact email	kongdezhi@hebmu.edu.cn
lab head
Dezhi Kong
contact affiliation	Hebei medical university
contact email	kongdezhi@hebmu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD034073

PRIDE project URI

• PRIDE
  1. PXD034073
     1. Label: PRIDE project
     2. Name: Proteomics of Human Hepatoma Huh-7 Cells Treated by Three Multi-RTK Inhibitors