PXD034053

PXD034053 is an original dataset announced via ProteomeXchange.

Title	Consequences of loss of spinophilin on striatal mGluR5 phosphorylation and interactome
Description	Constitutive knockout of the obsessive-compulsive disorder-associated protein, SAPAP3, results in repetitive motor dysfunction, such as excessive grooming, caused by increased mGluR5 activity in striatal medium spiny neurons (MSNs). However, signaling mechanisms that mediate mGluR5-dependent grooming dysfunction are not fully understood. Here, we investigate the function of the striatal signaling hub protein, spinophilin, in regulating mGluR5 phosphorylation and protein interactions, which may predict spinophilin’s role in regulating mGluR5-dependent grooming dysfunction.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:56:50.997.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD034053
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Emma Doud
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-25 01:02:09	ID requested
1	2022-12-14 06:28:52	announced
⏵ 2	2023-11-14 08:56:51	announced	2023-11-14: Updated project metadata.

10.6019/PXD034053;

submitter keyword: phosphatase targeting proteins, striatum, mouse,TMT-LC/MS

Amber L. Mosley
contact affiliation	Center for Proteome Analysis, Indiana University School of Medicine, Indianapolis, IN
contact email	almosley@iu.edu
lab head
Emma Doud
contact affiliation	Indiana University School of Medicine
contact email	edoud@iu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/12/PXD034053

PRIDE project URI

• PRIDE
  1. PXD034053
     1. Label: PRIDE project
     2. Name: Consequences of loss of spinophilin on striatal mGluR5 phosphorylation and interactome