PXD034004

PXD034004 is an original dataset announced via ProteomeXchange.

Title	Nanoparticle Elasticity Affects Systemic Circulation lifetime by Modulating the Adsorption of Apolipoprotein A-I in Corona Formation
Description	Nanoparticle elasticity plays crucial roles in determining nanoparticles’ physiological performances. However, the underlying mechanisms by which nanoparticle elasticity does so remain unknown.Using core-shell nanoparticles with a same PEGylated lipid bilayer shell yet cores differing in elasticity (45 kPa – 760 MPa) as the models, we isolated the effects of nanoparticle elasticity from those of other physiochemical parameters and observed a surprisingly non-monotonic relationship of nanoparticle elasticity versus nanoparticle systemic circulation lifetime, which segmented into three distinct regions depending on nanoparticle elasticity.
HostingRepository	iProX
AnnounceDate	2022-05-20
AnnouncementXML	Submission_2022-09-28_23:50:27.742.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tao Liu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-20 01:15:56	ID requested
1	2022-05-20 01:16:10	announced
⏵ 2	2022-09-28 23:50:28	announced	2022-09-29: Update publication information.

Li M, Jin X, Liu T, Fan F, Gao F, Chai S, Yang L, Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation. Nat Commun, 13(1):4137(2022) [pubmed]

submitter keyword: ApoA1, Protein corona

Minyang Li
contact affiliation	School of Chemistry and Materials Science, University of Science and Technology of China
contact email	lmyang@mail.ustc.edu.cn
lab head
Tao Liu
contact affiliation	School of Chemistry and Materials Science, University of Science and Technology of China
contact email	liutaoyq@mail.ustc.edu.cn
dataset submitter

iProX dataset URI